The Single Best Strategy To Use For ceesdekker
The Single Best Strategy To Use For ceesdekker
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Applying one-molecule optical and AFM imaging and power-spectroscopy methods, we seek to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our study pursuits incorporate:
You regularly become involved in discussions about science and religion. You've also penned many books on the subject. Don’t you believe that in some unspecified time in the future We'll know everything Which God’s role might be more than?
[Laughs] ‘It was definitely a great risk! At some time, I had been very well informed that it could go Mistaken and that I could turn out to be a lot less effective, but I just ignored that. Curiosity has usually been my strongest driving force. And fortunately all of it worked out.’
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
2010, designed a different way (‘wedging transfer’) to govern nanostructures; first report of DNA translocation via graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into reliable-condition nanopores
Our investigate ranges within the biophysics of DNA to artificial cells and outside of. You should take a look under with the spectrum of our recent assignments.
All parameters have been the exact same for every panel During this video, except for the Preliminary placement in the 6hb rod (demonstrated in blue) about the nanopore. Simulations that terminated early as a consequence of translocation of the rod through the pore are marked by a grey background.
Nanopores signify an elegant and versatile tool to measure one molecules. We research novel detection modes with solid-point out nanopores as well as many ways to evaluate proteins with nanopores. Jobs encompass the subsequent:
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Bulk-area coupling identifies the mechanistic relationship in between Min-protein patterns in vivo and in vitro
Screening pseudotopological and nontopological products for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments
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Developments in nanotechnology from the nineteen nineties built creating electronic gadgets from single molecules a chance. Cees Dekker recounts how his crew developed a area-temperature transistor determined by an individual carbon nanotube.
Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and one-molecule experiments